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Lymphatic filariasis is a neglected tropical disease commonly known as elephantiasis, which impairs the lymphatic system and can lead to the abnormal enlargement of body parts, causing pain, severe disability and social stigma.
Due to parasitic nematode Wuchereria bancrofti, Brugia malayi and B. timori which is transmitted by mosquitoes.
Endemic will is in approximately 72 countries throughout the tropics, with an estimated 1.39 billion people at risk.
Approximately 40,000,000 people have clinical manifestations of the disease, with 15 million having elephantiasis, and 25 million men have genital swelling including scrotal hydrocele.
Affects approximately 120 million people in Africa, Asia, Pacific, and the Americas.
Adult filarial worms live in the lymphatic systems and cause lymphedema of the legs, elephantiasis, and hydrocele.
Ivermectin/albendazole is also indicated for the treatment of microfilaraemia in people with lymphatic filariasis.
Ivermectin/albendazole is indicated for the treatment of cases of lymphatic filariasis caused by Wuchereria bancrofti, a parasite which is responsible for 90% of cases worldwide.