Lispro insulin (Humalog)

Insulin lispro, sold under the brand name Humalog among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes.

It is used by subcutaneous injection or within an insulin pump.

Onset of effects typically occurs within 30 minutes and lasts about 5 hours. 

Often a longer-acting insulin like insulin NPH is also needed.

Pregnancy category AU: A

Routes of administration Subcutaneous

Common side effects include low blood sugar, low blood potassium.

Use in pregnancy and breastfeeding is generally safe.

It increases the amount of glucose that tissues take in and decreasing the amount of glucose made by the liver.

Insulin lispro is used to treat people with type 1 diabetes or type 2 diabetes.

Common side effects include skin irritation at the site of injection, hypoglycemia, hypokalemia, and lipodystrophy.

Additional serious side effects include anaphylaxis, and hypersensitivity reactions.

Through recombinant DNA technology, 

the final lysine and proline residues on the C-terminal end of the B-chain are reversed by recombinant DNA technology, altering receptor binding, and blocking  the formation of insulin dimers and hexamers. 

This allows larger amounts of active monomeric insulin to be immediately available for postprandial injections.

Injection for use for diabetes mellitus to control hyperglycemia.

Should be used with longer acting insulin because of its rapid onset of action and shorter duration of action.

When used at mealtime should be used within 15 minutes before or after the meal.

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