Sensitivity of CSF cytological analysis only 40-80%.
Associated with aggressive non-Hodgkin’s lymphoma.
Flow cytometry more sensitive than cytological evaluation for occult disease.
The presence of 2 or more extranodal sites in aggressive NHL allow prediction of the presence of occult disease.
Risk for development of neoplastic meningitis includes the presence of an aggressive lymphoma subtype, such as Burkitt’s, lymphoblastic, or diffuse large B cell lymphoma, uncontrolled systemic disease, the presence of 2 or more extra nodal sites of metastases, especially uveoretinal, testicular, retroperitoneal and parasinal disease, and age younger than 60 years.