Langerhans cells

Localized in the epidermis and other squamous epithelia and are part of dendritic cell family.

Located in the skin and mucosa.

The cells can be found in other tissues along with eosinophils and lymphocytes.

Play a role in skin immunity.

May trigger psoriasis.

Important for skin graft-versus-host disease.

Ingest foreign antigens and when activated migrate to T-cell areas of skin draining lymph nodes.

Express myeloid marker CD33 and generated from monocytes and from CD14 positive cells in the dermis, and from a lymphoid progenitor.

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