Isoniazid

Widely used for the management of active and latent tuberculosis.

Since the 1960’s it has been the main agent for the treatment of latent tuberculosis with treatment over 6-9 months.

Associated with hematologic, neurologic, pulmonary and dermatologic side effects.

Hepatocellular changes with asymptomatic liver enzyme elevations and fulminant liver failure may occur.

From 2004-2008 17 serious adverse events were reported for long term treatment of tuberculosis infection-severe liver disease.

The risks associated with isoniazid preventive therapy during pregnancy is greater than those associated with the initiation of therapy during the postpartum period

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