Interleukin-10 (IL-10)

Interleukin-10 (IL-10) is a  cytokine involved in regulating and controlling immune responses in the body. 

An immune regulatory cytokine with anti-inflammatory properties but with stimulatory functions on B cells and CD8 positive and T cells.

Frequently considered an immune-suppressive and tumor promoting cytokine.

Enhances the proliferation and survival of the differentiation, the expression of the major histocompatibility complex class I I molecules, immunoglobulins and isotype switching in B cells.

Inhibits secretion of type I helper T cytokines interleukin-2 and interferon gamma.

Secreted by a variety of cells and has effects on T cells, B. cells, myeloid cells and other cell types as well.

It limits the secretion of inflammatory cytokines such as TNF-alpha and IL-12.

Mutations in genes encoding the IL-10 receptor found in patients with early onset enterocolitis with a hyper inflammatory immune response in the intestine.

Considered a promoter of lymphoma.

One third of patients with interleukin-10 receptor deficiency develop B-cell lymphomas in the first decade of life.

The IL-10 receptor is expressed only on the hematopoietic cells and in particular on cells of the immune system.

Interleukin-10 (IL-10) is produced by various immune cells, including Tregs, macrophages, and dendritic cells.

It is an anti-inflammatory cytokine, acting on different immune cells playing a crucial role in downregulating immune activation and dampening excessive inflammatory responses. 

IL-10 inhibits the activity of immune cells, such as T cells, B cells, and macrophages. 

IL-10 can reduce the production of inflammatory cytokines and limit the proliferation and activation of these cells, preventing excessive immune responses.

IL-10 helps to reduce inflammation by suppressing the synthesis of pro-inflammatory molecules, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and interleukin-6 (IL-6). 

IL-10 helps to control inflammation and prevent tissue damage.

IL-10 plays a role in promoting immune tolerance, particularly in the context of allergies and autoimmune diseases. 

It can modulate the response of immune cells to self-antigens or allergens, reducing the risk of immune-mediated reactions.

IL-10 is involved in tissue repair and regeneration,  reducing excessive scarring and modify wound healing responses.


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