Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@ gene.

IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations of IGHV are associated with better responses to some treatments and with prolonged survival.

In IGHV mutated CLL  patients  treated with FCR (Fludarabine, cyclophosphamide, Rituximab) chemo immunotherapy as many is 60% of patients will have long-term progressive free survival suggestive of a cure.

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