Hypofractionated radiation

Refers to radiation treatment in which the total dose of radiation is divided into large doses and treatments are given once a day or less often.

Dose fractionation effects are utilized in the treatment of cancer with radiation therapy. 

Is given over a shorter period of time (fewer days or weeks) than standard radiation therapy.

The trend toward shorter courses of definitive radio therapy with hypo fractionation, is a result of the availability of better imaging, planning, and radiotherapy technology, which allows significantly more precise treatment delivery.

Hypofractionation regimen delivers higher doses of radiation in fewer visits. 

Applying greater amounts of radiation works to lower the effects of accelerated tumor growth that typically occurs during the later stages of radiotherapy.

The radiation doses delivered to nontarget tissues has declined dramatically resulting in shorter treatment courses.

Randomized trial for treatment of intermediate risk prostate cancer is not inferior to standard RT (Catton CN).

May improve patient convenience and reduce treatment costs.

Post mastectomy hypo fractionated radiotherapy is non-inferior to and has similar toxicities to conventional fractionated radiotherapy in patients with high risk of breast cancer(Wang S-L).

Hypofractionated radiotherapy is noninferior to conventional radiotherapy in men with low-risk prostate cancer, yielding no differences in prostate cancer specific and general quality of life, as well as in anxiety and depression.

Treatment with hypofractionated radiotherapy is noninferior to conventional radiotherapy in men with low-risk prostate cancer in terms of disease-free survival and, in prostate cancer-specific and general QOL, as well as in anxiety and depression.

Hypofractionated  radiation therapy for prostate cancer  is associated with a greater than 9% risk of acute grade 2 or higher G.I. toxic affects compared with conventional fractionated radiation therapy, the use of a hyaluronic acid rectal spacer should be considered in patient receiving hypo fractionated radiation therapy for prostate cancer.

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