Individuals who are not acclimatized and ascend rapidly to high altitude environments are at risk for a number of the debilitating and potentially lethal illnesses.
The primary risk factor for acute altitude illness is rapid ascent.
High altitude illnesses include: high altitude headache, acute mountain sickness, high altitude cerebral edema, and high altitude pulmonary edema.
Symptoms may occur in the first days after arrival at high altitudes.
2500 m is the traditional threshold for high altitude illnesses.
Rarely mild illness may occur in persons who have ascended above 2000 m but below 2500 m.
Cerebral and pulmonary syndromes that can develop after ascent to high altitude.
The slower the ascent, the greater the time for acquisition and the lower the risk of altitude illness.
Once above 3000 m patients should not increase their sleeping elevation by more than 500 m per night and should include rest days every 3 to 4 days with sleep at the same elevation for at least two consecutive nights.
Nausea and vomiting may progress acute mountain sickness to high-altitude cerebral edema.
The absence of headache or other symptoms of acute mountain illness does not rule out the development of high altitude cerebral edema.
High-altitude cerebral edema usually develops after two days at altitudes above 4000 m, and the prevalence is estimated to be 0.5-1% among persons at that elevation.
High-altitude cerebral edema is associated with MRI changes of cerebral vasogenic edema and micro hemorrhages primarily in the corpus callosum.
Increased serum levels of IL-6, IL-6 receptor, and C reactive protein at elevtions higher than 3400 m.
At 8400 m healthy individuals have severe hypoxia.
Surveys show that individuals who travel to high altitude: 15% are over age 60 and 33% reported pre-existing medical problems.
The most common pre-existing medical conditions include hypertension, thyroid disease, asthma, and diabetes.
Alveolar hypoxia precipitates hypoxic pulmonary vasoconstriction, which increases pulmonary vascular resistance and pulmonary artery pressure, this is usually well tolerated but in persons with pulmonary hypertension, right heart failure, or both in may confer a predisposition to high altitude pulmonary edema or worsening right heart function.
Hypobaric hypoxia is clear risk for patients with sickle cell disease, inadequately controlled coronary disease or heart failure, high risk pregnancy, or neurologic condition such as vascular malformations or space occupying lesions.
Decreased humidity in the air temperature and increased exposure to UV light occur in the mountain environment, but its most important environmental variable is a decrease in barometric pressure that occurs with ascent.
Barometric pressure decrease reduces the Po2 along the oxygen transport chain from inspiration of air to organ and tissue oxygenation.
This sets in motion physiological responses to restore the concentration of oxygen and support metabolic demand.
A key mediator in responses of decreased PO2 is the hypoxia-inducible factor, a gene transcription factor that regulates cellular responses to hypoxia including cellular metabolism, angiogenesis, and erythropoiesis.
The primary prevention of acute mountain illness, high altitude, cerebral edema and high altitude pulmonary edema for travel above 2500 m (8202 feet) includes gradual ascent, limiting sleeping elevation increase to no more than 500 m per day and including a rest day without elevation gain every 3 to 4 days.
Pharmacologic prophylaxis for prevention of acute mountain sickness is reserved for those with a history of acute altitude altitude illness, particularly recurrent episodes, and for those planning a moderate to high risk ascent.
Prophylaxis against high altitude pulmonary edema with pulmonary vasodilators, including nifedipine and tadalafil, is reserved for persons with a history of this condition.
Patients with lung diseases of sufficient severity including COPD, interstitial lung disease, cystic fibrosis, cyanotic congenital heart disease, are at increase risk for exaggerated hypoxemia at any elevation.