Hepatosplenic T-cell lymphoma


Hepatosplenic T-cell lymphoma is a rare type of high-grade non-Hodgkin lymphoma that grows in the liver and spleen. 



It usually affects younger adults, typically people in their mid-30s. 



It is more common in men than women.



Hepatosplenic T-cell lymphoma is linked with immune deficiency: more common in patients on medicines that suppress the immune system – after a transplant or for inflammatory bowel diseases such as Crohn’s disease. 



It can occur spontaneously in people who don’t have pre-existing conditions and aren’t taking medication.



Common problems of hepatosplenic T-cell lymphoma are: hepatomegaly, 


ascites, jaundice, splenomegaly, 


anemia, thrombocytopenia and 


neutropenia, and weight loss.



It is mot associated with lymphadenopathy.



Most people with hepatosplenic T-cell lymphoma have advanced stage lymphoma at diagnosis.



No treatments have become established as recognized standard of care for hepatosplenic T-cell lymphoma. 



The most common chemotherapy regimens used for hepatosplenic T-cell lymphoma are those used for aggressive lymphomas.



HSCT are considered for responders.



Relapsed or refractory hepatosplenic T-cell lymphoma is common.






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