An organized compact collection of mature mononuclear phagocytes.

An inflammatory reaction to infectious and non-infectious processes.

Described as small collections of macrophages, which occur when the body tries to fight an infection, including fungus in bacterial infections.

Granulomatous disease refers to processes characterized by granulomas.

Macrophages are the characteristic cells in a granuloma.

Macrophages are tightly clustered in a ball-like shape.

A non-specific type of inflammatory response to diverse antigenic agents or by inert foreign materials.

Antigens trigger T cells and macrophages.

Formed as a result of interaction of cytokines produced by T cell lymphocytes and macrophages.

Antigens that may be responsible for triggering the reaction to form granuloma include: mycobacterium, fungi, beryllium, sarcoidosis, and foreign bodies.

Common infections and diseases that cause granuloma include: histoplasmosis, tuberculosis, cryptococcosis, sarcoidosis, Wegener’s granulomatosis, pulmonary rheumatoid nodules, aspiration of food or other particles into the lung.

Pulmonary hamartomas account for 10% of benign, solid, call my nodules.

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