Cytokines promoting the proliferation and differentiation and of neutrophils include IL3, IL6, G-CSF, and GM-CSF, the last two of which serve as the primary regulators of granulopoiesis.

Neutrophils are produced in large numbers, survive a short time and production is up-regulated in response to inflammation or infection.

Following mitosis progenitors mature to neutrophils in the bone marrow over several days.

The marrow reserve exceeds circulating neutrophils are 5-10 fold.

Neutrophils released from the bone marrow reserve is the main contributor of acute leukocytosis.

Circulating granulocytes circulate for a variable period of time and then enter tissues.

Daily white blood cell production is in the range of 10 to the 10th to 10 to the 11th .

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