Gram negative sepsis

Often complicated by vascular collapse, disseminated intravascular coagulation or vascular leak syndrome.

Lipopolysaccharide may be responsible for the endothelial damage.

Multiple organ failure is a frequent complication and is characterized by microvascular injury and vascular endothelial permeability.

Bacterial cell wall endotoxin, proinflammatory and anti-inflammatory proteins are released from cells which up-regulate coagulation proteases.

Coagulation proteases such as thrombin stimulate inflammatory cytokines which then propagates the procoagulant state with DIC, multiple organ failure and death.

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