A peptide hormone secreted primarily by the stomach and secondarily from the small intestine and colon.

Ghrelin released from the stomach, is also known as the hunger hormone because it stimulates food intake.

Ghrelin is a short-term factor secreted by the stomach just before an expected meal, and strongly promotes food intake. 

The physical sensation of hunger is related to contractions of the stomach muscles. 

Hunger pangs are believed to be triggered by high concentrations of the ghrelin hormone. 

Produced by the interior endocrine cells of the GI tract…

Secreted by oxyntic glands of the gastric epithelium, accounting for 60-70% of circulating levels.

Regulates growth hormone by acting as a growth hormone secretagogue-receptor ligand.


When insufficient food is present in the stomach and ghrelin levels are high, receptors in the hypothalamus initiate the sense of hunger.

Acts as a growth hormone releasing hormone predominantly via hypothalamic mechanisms.

28 amino acid acylated peptide.

Increases food intake.

An orexigenic hormone.

Ghrelin-reactive IgG immunoglobulins affect ghrelin’s orexigenic response.

Ghrelin and leptin are released from the stomach and adipose cells, respectively, into the blood stream. 

Ghrelin stimulates feelings of hunger, whereas leptin stimulates feelings of satisfaction from food.

Obese individuals have reduced levels.

Weight-loss, that is, dieting increases gherlin levels.

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