Gefapixant, a P2X3 receptor antagonist.

It  blocks the adenosine triphosphate-gated ion channel on chemically sensitive airway, C-fibers, and has the potential to decrease cough by reducing activation of airway, C-fibers that transmit action potential‘s to the brain.

It is used for refractory or unexplained chronic cough. 

Has small/marginal effects in improving cough compared with placebo. 

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