Gefapixant, a P2X3 receptor antagonist.
It blocks the adenosine triphosphate-gated ion channel on chemically sensitive airway, C-fibers, and has the potential to decrease cough by reducing activation of airway, C-fibers that transmit action potential‘s to the brain.
It is used for refractory or unexplained chronic cough.
Has small/marginal effects in improving cough compared with placebo.