Gamma-glutamyl carboxylase

Vitamin K dependent gamma carboxylase localized in the endoplasmic reticulum and is a transmembrane protein.

Substrates are the vitamin K dependent coagulation factors prothrombin, factor VII, factor IX, factor X, protein C, protein S and protein Z.

Requires reduced vitamin K as an obligate cofactor.

Warfarin inhibits vitamin K epoxide reductase (VKOR) and blocks the regeneration of active reduced vitamin K

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