Vitamin K dependent gamma carboxylase localized in the endoplasmic reticulum and is a transmembrane protein.
Substrates are the vitamin K dependent coagulation factors prothrombin, factor VII, factor IX, factor X, protein C, protein S and protein Z.
Requires reduced vitamin K as an obligate cofactor.
Warfarin inhibits vitamin K epoxide reductase (VKOR) and blocks the regeneration of active reduced vitamin K