Assigns an absolute risk number to risk factors for breast cancer for the next 5 years as well as for the patient’s lifetime.
Utilizes patient’s age, number of first-degree relatives with a breast cancer, pregnancy history, age at menarche, number of prior breast biopsies, and previous diagnosis of atypical hyperplasia or lobular cell in situ.
Other risk factors include age at first live birth and ethnicity.
Does not include risk indicators ovarian cancer, paternal family history and age at onset.
Underestimates genetically associated risks and is more accurate in assessing risk of breast cancer development in women with moderate risk levels.
FDA defines increased breast cancer risk as equal or greater than 1.66% equating to the 5-year risk of an average 60 year old white woman.
breast cancer screening recommendations for individuals 35 years or older with a five year risk of invasive breast cancer of 1.7% or greater is recommended.