Fetal hemoglobin

Contains two alpha chains and two gamma chains with a higher O2 affinity than adult hemoglobin A
composed of two alpha and two beta chains.

Known also as hemoglobin F.

Most adults have hemoglobin F levels that average about 1%.

In patients with sickle cell disease higher concentrations and had fibin F (HbF) associated with milder clinical disease, with fewer painful crises and adverse events.

Hemoglobin F inhibits polymerization of sickle hemoglobin.

Hydroxyurea lowers the frequency of painful crises, acute chest syndrome, and transfusions in adults with sickle cell disease by increasing hemoglobin F levels.

Starting hydroxyurea at a young age in sickle cell patients can sustain HbF levels at 20%.

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