Eugeroics are wakefulness-promoting agents.


A class of drugs that promote wakefulness and alertness.


Such agents are medically indicated for the treatment of sleep disorders including excessive daytime sleepiness in narcolepsy or obstructive sleep apnea.


These drugs have a very low addictive potential.


Offten prescribed off-label for the treatment of excessive daytime sleepiness in idiopathic hypersomnia.

The latter is a rare and often debilitating sleep disorder which currently has no official treatments approved by the Food and Drug Administration (FDA). 

Contrasted   with psychostimulants, such as methylphenidate and amphetamine, also used in the treatment of these disorders, eugeroics typically do not produce euphoria, and, consequently, have a lower addictive potential.

Modafinil and armodafinil are each thought to act as selective, weak, atypical dopamine reuptake inhibitors.

Modafinil and Armodafinil (Nuvigil) act as a selective, weak, atypical dopamine reuptake inhibitor.

Adrafinil acts as a prodrug for modafinil.

Other stimulants:


Sodium oxybate







Other eugeroics include solriamfetol, a norepinephrine–dopamine reuptake inhibitor (NDRI), and pitolisant, which acts as a histamine 3 (H3) receptor antagonist/inverse agonist.

Armodafinil (Nuvigil)

Modafinil (Provigil)

Pitolisant (Wakix)

Solriamfetol (Sunosi)


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