Are gram-negative rods and include E.Coli, Klebsiella, Enterobacter, S2242atia, Salmonella, Proteus and Shigella.

Gut or genitourinary related pathogens.

Among most common pathogens among humans.

Disease processes range from cystitis, pneumonia, bacteremia, meningeal disease, and peritonitis.

Increasingly developing multiorgan resistance by acquiring genes for extended spectrum Beta lactaminases (ESBL)s.

Carbapenems have been used recently to overcome increasing antibiotic resistance.

Recently carbapenem resistance has developed to Enterobacteriaceae, without other reliable treatments.

Carbapenem resistant Enterobacteriaceae (CRE) caused by hydrolyzing enzymes.

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