Persistent or recurrent pain or discomfort in epigastric area which is associated with fullness, early satiety, bloating, nausea and belching.

Up to 40% of adults experience symptoms at least once a year.

About 80% of patients with dyspepsia have normal findings on esophagogastroduodenoscopy.

Most patients have functional dyspepsia with no findings, but other causes include peptic ulcer disease (15-25%), Helicobacter pylori infection (30-60%), gastrointestinal reflux disease gastric cancer and secondary to use of drugs such associated nonsteroidal anti-inflammatory drugs.

Empiric acid suppressive therapy without diagnostic examination is reasonable in patients less than 45 years of age.

Work-up may include upper gastrointestinal endoscopy, esophageal pH monitoring, gastric emptying times studies and water load tests.

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