Vaccination at 2 months, 4 months, 6 months provide 70%-80% protection, therefore a fourth dose is often added between 15 and 18 months.
Tdap vaccine for tetanus toxoid, reduced deiptheria toxoid and acellular pertussis vaccine (Tdap) for individuals aged 10-64 as a single dose booster immunization.
Adolescents 11-18 who have completed childhood DTP vaccination series should receive a single dose Tdap instead of tetanus and diptheria toxoids (Td).
For adults 19-64 a single dose og Tdap will replace Td boosters.
Whole-cell Pertussis vaccine as an associated with neurologic illnesses characterized by seizures and intellectual impairment, but recent studies indicate that it can trigger earlier onset of severe epileptic encephalopathy children with sodium channel gene mutation.
Presently acellular pertussis vaccine has replaced the whole-cell pertussis vaccine with fewer adverse effects, including fever.
Associated with a twofold higher risk of seizures on the day of diphtheria- tetanus toxoids-a cellular pertussis- inactivated poliovirus-Haemophilus influenza type B vaccination, with a 30% higher risk for the day of the first DTaP vaccination.