CERVIDIL (dinoprostone) Vaginal Insert.

A drug used to prepare the cervix for the induction of labor in pregnant women who are at or near term.

Commonly known as prostaglandin E2 or PGE2.

Dinoprostone comes as a vaginal insert and as a gel that is inserted high into the vagina.

It is administered vaginally using a syringe, by a health professional in a hospital or clinic setting.

After administration the patient remains lying down for up to 2 hours.

A second dose of the gel may be administered in 6 hours if the first dose does not produce the desired response.

Side effects are uncommon:

upset stomach




flushing of the skin



Dinoprostone gel should be stored in a refrigerator.

The vaginal inserts should be stored in a freezer.

Dinoprostone is released at a rate of approximately 0.3 mg/hr.

CERVIDIL® dinoprostone vaginal is the trade name.

Cervidil Vaginal Insert of 10 mg) is indicated for the initiation and/or continuation of cervical ripening in patients at or near term in whom there is a medical or obstetrical indication for the induction of labor.

The vaginal insert is 10 mg designed to be released at approximately 0.3 mg/hour over a 12 hour period.

It should be removed upon onset of active labor or 12 hours after insertion.

The insertion of the vaginal insert does not require sterile conditions.

Patients should remain in the recumbent position for 2 hours following insertion, and if uterine hyperstimulation is encountered or if labor commences, the vaginal insert should be removed.

A vaginal exam should be performed to remove the slab.

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