DES daughters

Diethylstilbestrol, the first synthetic estrogen, was used to prevent pregnancy complication, without efficacy.

Has not been prescribed for pregnant women for more than 40 years.

Born to mothers who used antimiscarraige drug diethylstilbestrol during pregnancy.

Great increase in risk of development of rare cancers of the vagina and cervix.

Intrauterine exposure of diethylstilbestrol associated with clear cell adenocarcinoma of the cervix and vagina in adolescents.

Are at substantial risk for the development of breast cancer.

Cumulative risks for women exposed to DES in utero: infertility,33.3%, spontaneous abortion,50.3%, preterm delivery, 53.3%, loss of second trimester pregnancy, 16.4%, ectopic pregnancy, 14.6%, preeclampsia, 26.4%, stillbirth 8.9%, early menopause, 5.1%, CIN 6.9%, and breast cancer at 40 years or older 3.9% (Hoover RN et al).

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