A transmembrane pattern recognition receptor that can sense Beta-glucan component of fungal cell walls.

Pattern recognition receptors of the immune system binds microbial components and initiate intracellular signal cascades that result in activation of transcription factors, can upregulate defense associated target genes, and release cytokines (H2242e J).

Sends signals through tyrosine based immunoreceptor activation motif (ITAM), which when phosphorylated by Src family kinases leads to recruitment and activation of the spleen tyrosine kinase (Syk) (Underhill DM.)

Dectin-1-Syk engages intracellular adapter molecule CARD9 and helps to form an intracellular signaling complex in cells that recognizes fungi, and leads to the activation of cytokines IL-1Beta, IL-6 and IL-23 that control antifungal immunity.

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