The CytoSorb Device (CytoSorb) is a non-pyrogenic, sterile, single-use device containing adsorbent polymer beads designed to remove cytokines, as blood passes through the device.
CytoSorb is placed in a blood pump circuit.
CytoSorb is indicated for use in conditions where elevated levels of cytokines are present.
Maximum treatment time per device: 24 hours.
Day 1: Change device every 12 hours; Day 2: Change device at 24 hours; Day 3: Change device at 24 hours.
Maximum Blood Flow Rate: 700 mL/min.
Minimum Blood Flow Rate: 100 mL/min
Recommended Blood Flow Rate: 150-500mL/min
Caution should be used at low flow rates as the potential for clotting may increase.
Contraindications
• marked thrombocytopenia
Any pre-existing contraindication to extracorporeal therapy
Known allergies to extracorporeal circuit components
History of heparin-induced thrombocytopenia
Acute sickle cell crisis.
Morbid obesity with BMI ≥ 40 kg/m2
Any pre-existing advanced medical disease with life-expectancy less than 1 month
Treatment deemed clinically futile
Pregnancy
Relative Contraindications
Concomitant use of corticosteroids
Patients who are profoundly immune suppressed
Complications associated with extracorporeal therapies include blood loss due to leaks, hypothermia, dyspnea, hypoxia/hypotension, and death due to air embolism.