A protein that helps regulate cell progression through G1/S phase of the cell cycle.
Cyclin D is a protein that plays a crucial role in the cell cycle, specifically during the G1 phase.
Cyclin D acts as a regulatory protein that helps control the transition from the G1 phase (the first gap phase) to the S phase (DNA synthesis).
It does this by forming a complex with a protein kinase called CDK4 or CDK6.
This complex, known as cyclin D-CDK4/6 phosphorylates proteins that are crucial for cell cycle progression.
Cyclin D’s activity is linked to cell growth signal factors.
When cells receive these signals, they activate the production of cyclin D, which then activates CDK4/6, leading to cell cycle entry and ultimately, cell growth.
The dysregulation of cyclin D expression and activity has been implicated in various types of cancer: an overexpression of cyclin D, leading to uncontrolled cell growth.
Mutations in the cyclin D gene can lead to its inactivation, which can disrupt normal cell cycle.
When cells receive growth factors, such as epidermal growth factor or platelet-derived growth factor, it triggers a signaling cascade.
This signaling cascade ultimately leads to the transcription of the cyclin D gene.
The newly synthesized cyclin D protein binds to CDK4 or CDK6, forming the active cyclin D-CDK4/6 complex.
Overexpressed in mantle cell lymphoma.
Antibodies to this protein seen in nearly all cases of hairy cell leukemia.