Core Binding Factor is a heterodimeric transcription factor that consists of a DNA binding α-subunit, encoded by one of three members of the RUNX family and a β-subunit encoded by the CBFβ gene that increases DNA-binding affinity to the complex.
Mutations involving CBF rearrangements occur in 15% of cases of AML and are associated with a favorable prognosis.
CBFβ also modulates the effect of CBFβ-SMMHC in adult hematopoiesis and leukemogenesis.