C immitis a fungal organism acquired by inhalation.

Caused by soil fungi of the genus Coccidioides, divided into Coccidioides immitis, endemic to California, and Coccidioides posadasii, isolated outside of California.

Coccidioides is a dimorphic fungi that grows as a white mold at 77-86°F.

Fungus occurs naturally only in the Western Hemisphere an primarily in southwest U.S. and Mexico.

Fungus endemic in arid to semiarid climate, with hot summers, low altitude, alkaline soil and sparse vegetation-California and Arizona.

About 150,000 cases occur annually in the U.S.

Presentation ranges from a self-limited respiratory illness to a life threatening process.

Most commonly presents as a self limited upper respiratory tract infection in endemic areas.

Most infections are asymptomatic or cause minor respiratory disease.

Clinical disease, however, apparently develops in 1/3 of person is exposed to Coccidioides.

About 1% of infections progressed to disseminating coccidiomycosis, defined as spread beyond the lungs and often involving bones, CNS, and skin.
Disseminated Coccidiomycosis causes serious illness with prolong disease course, permanent tissue damage, and a fatality rate exceeds 40%.
Treatment of disseminators disease often requires lifelong receipt of antifungal agents, since infections may be chronic work or completely cleared.

Patients generally develop a flu like syndrome with cough and fever.

It can manifest as lobar or segmental pneumonia with hilar adenopathy.

60% of people are asymptomatic.

Most infections are self-limited pulmonary infections acquired in the Southwestern US where the fungus is endemic.

About 75% of cases occur in Arizona in 25% in California.

Coccidioides hyphae produce barrel shaped arthroconidia.

Coccidioides arthroconidia in body tissues or fluids enlarge and develop into spherules containing endospores.

Most infections are caused by inhalation of spores.

60% of infected individuals remain asymptomatic.

Approximately 1 in 200 infected patients develop disseminated disease, which can develop multiple years after initial infection.

Inhaled organisms transform in the bronchioles into spherules and cause pulmonary infection.

Disseminated disease usually found in persons with altered cell immunity including patients with AIDS, Hodgkin’s disease and post solid organ transplant.

Pulmonary coccidiomycosis really progresses to acute respiratory distress syndrome, in which mortality may approach 100%.

Coccidioidal pneumonia most commonly presents with chest pain, cough and fever, while other symptoms include fatigue, dyspnea, headache, sore throat, and arthralgias.

Less commonly hemoptysis and erythema nodosum are present.

In immunocompetent individuals severe disseminated diseases is rare with an incidence of less than 1%.

Eosinophilia is noted in the peripheral blood in 25-30% of cases, and may help in differentiating coccidiomycosis pneumonia from a bacterial pneumonia.

Immune response to Coccidioides immunities is highly dependent to T cell lymphocytes.

Risk factors for severe or disseminated disease include racial heritage, pregnacy, or cell mediated immunodeficiency.

Corticosteroids have been found to increase the risk for coccidiomycosis but has been reported to be effective in treating patients with severe symptomatology.

Filipinos have the highest risk of dissemination, about 10-175 times the risk of Caucasians.

Blacks at significantly higher risk of developing disseminated disease.

Blacks have a 5 times higher risk of developing meningitis than whites and Filipinos have a 10 times higher risk.

Coccidioides can cause a lethal meningitis that develops within weeks to months after and often unrecognized primary infection.

Coccidioides meningitis typically has increased lymphocytes in the CSF.

Persons with group B blood type at higher risk for disseminated disease.

Patients with eosinophilia and high Ig levels have a worse prognosis.

Other groups with the increased risk for severe disease include pregnant women, infants, patients who have undergone thymectomy, patients with cancer, diabetes, or those immunocompromised.

Dissemination is typically to the skin with predilection to the nasolabial fold, bones, joints, meninges, and pleural space.

Mortality rate of non HIV infection hospitalized patients in California associated with a mortality rate of 8.2% ,while HIV infected patients had a mortality was24%(Flaherman ).

Disease outcomes depends on cellular immunity.

Resolution of infection is associated with the robust interfere on Gamma-mediated type 1 immune responses, which require the cytokine Interleukin-12 for initiation.

Heavy rains promote dispersion of agent by promoting growth in the soil and drought subsequently causes aerosolization of arthroconidia (Kolivras).

Outbreaks may be a result of atmospheric soil dispersion related to dust storms droughts, and earthquakes.

Occupational exposure in agricultural workers, excavators, military, archeologists are at highest risk for the development of this process.

Immunocompromised individuals including those with: AIDS/HIV, transplant recipients, patients receiving tumor necrosis factor inhibitors, pregnant women and patients with malignancy at high risk of this infection.

Treatment of coccidioidomycosis with fluconazole is indicated for the meningeal form due to adequate CSF penetration and limited toxicity compared with amphotericin B.

Therapy is lifelong at doses of at least 400 mg daily.

Fluconazole is also effective for nonmeningeal forms of this disease, but itraconazole is preferred due to possible increased efficacy for skeletal infections.

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