Claudins are a family of proteins which, along with occludin, are the most important components of the tight cell junctions.
Tight junctions establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium
Claudins are crucial components of tight junctions.
They are small transmembrane proteins containing typically four transmembrane domains and two extracellular loops.
The claudin family consists of approximately 27 proteins that locate differentially in different tissues.
Tight junctions at the paracellular barrier control the flow of molecules in the intercellular space between the cells of an epithelium.
Their altered function has been linked to various cancers, which makes them potential targets for diagnostics and therapeutic moda
Claudin 18.2 is the isoform 2 of Claudin-18 protein.
Its expression in normal tissues is strictly confined to differentiated epithelial cells of the gastric mucosa
CLDN18.2 is highly expressed in certain primary malignant tumors, such as gastric cancer, breast cancer, colon cancer and liver cancer.
Its expression is also present in pancreatic, esophageal, ovarian, and pulmonary tumors.
Its abnormal expression in various epithelial tumors indicates that CLDN18.2 may play an important role in tumor invasion and metastasis.
CLDN18.2 is often linked with proliferation and chemotaxis of cells in gastric cancer.
CLDN18.2 is expressed in 50 – 70% of primary gastric adenocarcinomas and their metastases.
Tight junctions have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm.
Their altered function has been linked to various cancers, which makes them potential targets for diagnostics and therapeutic moda
Claudin 18.2 is the isoform 2 of Claudin-18 protein.
Its expression in normal tissues is strictly confined to differentiated epithelial cells of the gastric mucosa
CLDN18.2 is highly expressed in certain primary malignant tumors, such as gastric cancer, breast cancer, colon cancer and liver cancer.
Its expression is also present in pancreatic, esophageal, ovarian, and pulmonary tumors.
Its abnormal expression in various epithelial tumors indicates that CLDN18.2 may play an important role in tumor invasion and metastasis.
CLDN18.2 is often linked with proliferation and chemotaxis of cells in gastric cancer.
CLDN18.2 is expressed in 50 – 70% of primary gastric adenocarcinomas and their metastases.
Claudins are small (20–24/27 kilodalton (kDa)) transmembrane proteins.
Claudins span the cellular membrane 4 times, with the N-terminal end and the C-terminal end both located in the cytoplasm, and two extracellular loops.
Cysteines of individual or separate claudins form disulfide bonds.
Claudins create both cis and trans strand formation between cell membranes.
In humans, 24 members of the Claidin family have been described.
Claudin 18.2 is exclusively present in gastric mucosal and is retained in malignant transformation.
Claudin 18.2 has a potential role in invasive phenotype of diffuse tumors.
It has been detected in both diffuse and intestinal gastric cancers as well as esophageal cancer.
Chimeric monoclonal I GG1 antibodies have been created for claudin 18.2.