Chromosome 6

Human chromosome 6 pair after G-banding.

One is from mother, one is from father.

Chromosome 6 is one of the 23 pairs of chromosomes in humans. 

People normally have two copies of this chromosome. 

Chromosome 6 spans more than 172 million base pairs.

Chromosome 6 DNA material represents between 5.5 and 6% of the total DNA in cells. 

Chromosome 6 contains the major histocompatibility complex, which contains over 100 genes related to the immune response, and plays a vital role in organ transplantation.

The human leukocyte antigen lies on chromosome 6, and encodes cell-surface antigen-presenting proteins among other functions.

Number of genes on chromosome 6  is 1,557 genes, and 633 pseudogenes.

The following is a partial list of genes on human chromosome 6.

The following are some of the genes located on p-arm (short arm) of human chromosome 6:

ADTRP: encoding protein Androgen-dependent TFPI-regulating protein

APOM: encoding protein Apolipoprotein M (6p21.33)

ATXN1: encoding protein Ataxin 1 (6p16.3-p16.76)

TSBP1: encoding protein TSBP1 (6p21.32)

C6orf62: chromosome 6 open reading frame 62 (6p22.3)

C6orf89: chromosome 6 open reading frame 89 (6p21.2)

CDKAL1: CDK5 regulatory subunit associated protein 1 like 1 (6p22.3)

COL11A2: collagen, type XI, alpha 2(6p21.3)

CYP21A2: cytochrome P450, family 21, subfamily A, polypeptide 2 (6p21.33)

DHX16: DEAH-box helicase 16 (6p21.33)

DOM3Z: Decapping exoribonuclease (6p21.33)

DSP: Desmoplakin gene linked to cardiomyopathy (6p24.3)

ELOVL5: ELOVL fatty acid elongase 5 (6p12.1)

FBXO9: F-box protein 9 (6p12.1)

FOXP4-AS1: encoding protein FOXP4 antisense RNA 1

FTH1P5: encoding protein Ferritin, heavy polypeptide 1 pseudogene 5

G6B: Protein G6b (6p21.33)

GCNT2: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (6p24.3)

GMDS: GDP-mannose 4,6-dehydratase (6p25.3)

HCG4P11: HLA complex group 4 pseudogene 11

HFE: hemochromatosis (6p22.2)

HIST1H2AH: histone cluster 1 H2A family member h (6p22.1)

HLA-A, HLA-B, HLA-C: major histocompatibility complex (MHC), class I, A, B, and C loci. (6p21.3)

HLA-DQA1 and HLA-DQB1 form HLA-DQ heterodimer MHC class II, DQ: Celiac1, IDDM (6p21.3)

HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 forms HLA-DR, heterodimer MHC class II, DR (6p21.3) Mold / Biotoxin Susceptibility

HLA-DPA1 and HLA-DPB1 forms HLA-DP, MHC class II, DP (6p21.3)

HLA-Cw*06:02: gene variation related to psoriasis (6p21.3)

LOC100533655: encoding protein Aryl hydrocarbon receptor pseudogene

LST1: leukocyte specific transcript 1 (6p21.33)

LY6G6E encoding protein Lymphocyte antigen 6 complex, locus G6E (pseudogene) (6p21.33)

MIR4640: microRNA 4640 (6p21.33)

MLIP: muscular LMNA interaction protein (6p12.1)

MRPS18B: mitochondrial ribosomal protein S18B (6p21.33)

MUT: methylmalonyl Coenzyme A mutase (6p12.3)

NHLRC1: NHL repeat containing E3 ubiquitin protein ligase 1 (6p22.3)

NOL7: nucleolar protein 7 (6p23)

NQO2: N-ribosyldihydronicotinamide:quinone reductase 2 (6p25.2)

NRSN1: neurensin 1 (6p22.3)

NUDT3: nudix hydrolase 3 (6p21.31)

PFDN6: prefoldin subunit 6 (6p21.32)

PHACTR1: phosphatase and actin regulator 1 (6p24.1)

PKHD1: polycystic kidney and hepatic disease 1 (autosomal recessive) (6p21.2-p12)

PRICKLE4: prickle planar cell polarity protein 4 (6p21.1)

PRSS16: protease, serine 16 (6p22.1)

PSMB8-AS1: PSMB8 antisense RNA 1 (head to head) (6p21.32)

RAB44: encoding protein Rab44, member ras oncogene family

RIPOR2: RHO family interacting cell polarization regulator 2 (6p22.3)

RPL10A: encoding protein 60S ribosomal protein L10a (6p21.31)

SKIV2L: Ski2 like RNA helicase (6p21.33)

SSR1: signal sequence receptor subunit 1 (6p24.3)

TCF19: transcription factor 19 (6p21.33)

TCP11: t-complex 11 (6p21.31)

TJAP1: tight junction associated protein 1 (6p21.1)

TP53COR1 encoding protein Tumor protein p53 pathway corepressor 1 (non-protein coding)

TMEM151B: encoding protein Transmembrane protein 151B

TNXB: tenascin XB (6p21.3)

TRAM2: translocation associated membrane protein 2 (6p12.2)

TRIM38: encoding protein Tripartite motif containing 38

TTBK1: encoding protein Tau tubulin kinase 1

UBR2: ubiquitin protein ligase E3 component n-recognin 2 (6p21.2)

UNC5CL: encoding protein Unc-5 homolog C (C. elegans)-like

VEGF: vascular endothelial growth factor A (angiogenic growth factor) (6p21.1)

VPS52: GARP complex subunit

ZKSCAN4: encoding protein zinc finger with KRAB and SCAN domains 4

ZNF76: zinc finger protein 76 (6p21.31)

ZNF193: zinc finger protein 193 (6p22.1)

ZNRD1: zinc ribbon domain containing 1 (6p22.1)

The following are some of the genes located on q-arm (long arm) of human chromosome 6:

AIM1: encoding protein Absent in melanoma 1 protein (6q21)

AIG1: encoding protein Androgen-induced protein 1 (6q24.2)

AKIRIN2: akirin 2 (6q15)

ARG1: arginase 1 (6q23.2)

BCKDHB: branched-chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) (6q14.1)

BMIQ3: body mass index QTL 3

TMEM242 encoding transmembrane protein TMEM242

C6orf58: chromosome 6 open reading frame 58 (6q22.33)

CFAP206: encoding protein Cilia And Flagella Associated Protein 206

CMD1F: cardiomyopathy, dilated 1F

CMD1K: cardiomyopathy, dilated 1K

CNR1: cannabinoid 1 receptor (6q14-q15)[13]

DFNB38: deafness, autosomal recessive 38

DYX4: dyslexia susceptibility 4

ECT2L: encoding protein Epithelial cell transforming sequence 2 oncogene-like

ESR1: Estrogen receptor 1 (6q25)

EYA4: eyes absent homolog 4 (Drosophila)(6q23.2)

FBXL4: F-box and leucine rich repeat protein 4 (6q16.1-q16.2)

FEB5: febrile convulsions 5

HACE1: HECT domain and Ankyrin repeat containing, E3 ubiquitin protein ligase 1 (6q21)

HEBP2: heme binding protein 2 (6q24.1)

IDDM8: insulin dependent diabetes mellitus 8

IDDM15: insulin dependent diabetes mellitus 15

IFNGR: interferon-γ receptor gene (6q23-q24)

IGF2R: insulin-like growth factor 2 receptor (6q25.3)

IMPG1: interphotoreceptor matrix proteoglylcan 1 (6q14.1)


LGSN: encoding protein lengsin

LIN28B: lin-28 homolog B (6q16.3-q21)

MAN1A1: mannosidase alpha class 1A member 1 (6q22.31)

MB21D1: encoding protein Mab-21 domain containing 1

MCDR1: macular dystrophy, retinal, 1

MDN1: midasin AAA ATPase 1 (6q15)

MOXD1: monooxygenase DBH like 1 (6q23.2)

MTO1: mitochondrial tRNA translation optimization 1 (6q13)

MRT18: mental retardation, non-syndromic, autosomal recessive

MRT28: mental retardation, non-syndromic, autosomal recessive

MTRF1L: mitochondrial translational release factor 1 like (6q25.2)

MYO6: myosin VI (6q14.1)

OA3: ocular albinism 3

OPRM1: μ-opioid receptors (6q24-q25)

OTSC7: otosclerosis 7

PLG: plasminogen (6q26)


PARK2: Parkinson disease (autosomal recessive, juvenile) 2, parkin (6q26)

PCMT1: protein-L-isoaspartate (D-aspartate) O-methyltransferase (6q25.1)

PERP: p53 apoptosis effector related to PMP-22 (6q23.3)

PKIB: cAMP-dependent protein kinase inhibitor beta (6p22.31)

PLAGL1: (6q24.2)

RCD1: retinal cone dystrophy 1

RFPL4B: Ret finger protein like 4B

RP63: retinitis pigmentosa 63

SASH1: SAM and SH3 domain containing 1 (6q24.3-q25.1)

SCZD5: schizophrenia disorder 5

SEN6: senescence (cellular)-related 6

SENP6: SUMO1/sentrin specific peptidase 6 (6q14.1)

SERAC1: serine active site containing 1 (6q25.3)

SERINC1: serine incorporator 1 (6q22.31)

SF3B5: splicing factor 3b subunit 5 (6q24.2)

SMAP1: small ArfGAP 1 (6q13)

SOBP: sine oculis binding protein homolog (6q21)

SPG25: spastic paraplegia 25

ST8: suppression of tumorigenicity 8

SYNJ2: synaptojanin 2 (6q25.3)

T: T brachyury transcription factor (more commonly known as the T gene) linked to Hepatocellular carcinoma and Chordoma (6q27)[14]

TAAR1: trace amine associated receptor 1 (6q23.1)

TAAR2: trace amine associated receptor 2 (6q24)

TMEM200A: encoding protein Transmembrane protein 200A

TSPYL1: TSPY like 1 (6q22.1)

UNC93A: encoding protein Unc-93 homolog A (C. elegans)

VNN1: vanin 1 (6q23.2)

VNN2: vanin 2 (6q23.2)

VTA1: Vesicle trafficking 1 (6q24.1-2)

ZC2HC1: encoding protein Zinc finger C2HC-type containing 1B

ZDHHC14: encoding protein Zinc finger, DHHC-type containing 14

The following diseases are some of those related to genes on chromosome 6:

ankylosing spondylitis, HLA-B

collagenopathy, types II and XI

Coeliac disease HLA-DQA1 & DQB1

Ehlers-Danlos syndrome, classical, hypermobility, and Tenascin-X types

Hashimoto’s thyroiditis


Hemochromatosis type 1

21-hydroxylase deficiency

maple syrup urine disease

methylmalonic acidemia

Autosomal nonsyndromic deafness

North Carolina macular dystrophy

otospondylomegaepiphyseal dysplasia

Parkinson disease

polycystic kidney disease


porphyria cutanea tarda

Rheumatoid arthritis, HLA-DR

CIRS (Chronic Inflammatory Response Syndrome ), Sick Building Syndrome, Mold Toxin Susceptibility / Poisoning, HLA-DR/DQ

Spinocerebellar ataxia type 1, ATXN1

Stickler syndrome, COL11A2

Systemic lupus erythematosus

Diabetes mellitus type 1, HLA-DR, DQA1 & DQB1

X-linked sideroblastic anemia


Guillain Barre Syndrome


Hepatocellular carcinoma


Cytogenetic band

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