Human chromosome 6 pair after G-banding.
One is from mother, one is from father.
Chromosome 6 is one of the 23 pairs of chromosomes in humans.
People normally have two copies of this chromosome.
Chromosome 6 spans more than 172 million base pairs.
Chromosome 6 DNA material represents between 5.5 and 6% of the total DNA in cells.
Chromosome 6 contains the major histocompatibility complex, which contains over 100 genes related to the immune response, and plays a vital role in organ transplantation.
The human leukocyte antigen lies on chromosome 6, and encodes cell-surface antigen-presenting proteins among other functions.
Number of genes on chromosome 6 is 1,557 genes, and 633 pseudogenes.
The following is a partial list of genes on human chromosome 6.
The following are some of the genes located on p-arm (short arm) of human chromosome 6:
ADTRP: encoding protein Androgen-dependent TFPI-regulating protein
APOM: encoding protein Apolipoprotein M (6p21.33)
ATXN1: encoding protein Ataxin 1 (6p16.3-p16.76)
TSBP1: encoding protein TSBP1 (6p21.32)
C6orf62: chromosome 6 open reading frame 62 (6p22.3)
C6orf89: chromosome 6 open reading frame 89 (6p21.2)
CDKAL1: CDK5 regulatory subunit associated protein 1 like 1 (6p22.3)
COL11A2: collagen, type XI, alpha 2(6p21.3)
CYP21A2: cytochrome P450, family 21, subfamily A, polypeptide 2 (6p21.33)
DHX16: DEAH-box helicase 16 (6p21.33)
DOM3Z: Decapping exoribonuclease (6p21.33)
DSP: Desmoplakin gene linked to cardiomyopathy (6p24.3)
ELOVL5: ELOVL fatty acid elongase 5 (6p12.1)
FBXO9: F-box protein 9 (6p12.1)
FOXP4-AS1: encoding protein FOXP4 antisense RNA 1
FTH1P5: encoding protein Ferritin, heavy polypeptide 1 pseudogene 5
G6B: Protein G6b (6p21.33)
GCNT2: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (6p24.3)
GMDS: GDP-mannose 4,6-dehydratase (6p25.3)
HCG4P11: HLA complex group 4 pseudogene 11
HFE: hemochromatosis (6p22.2)
HIST1H2AH: histone cluster 1 H2A family member h (6p22.1)
HLA-A, HLA-B, HLA-C: major histocompatibility complex (MHC), class I, A, B, and C loci. (6p21.3)
HLA-DQA1 and HLA-DQB1 form HLA-DQ heterodimer MHC class II, DQ: Celiac1, IDDM (6p21.3)
HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 forms HLA-DR, heterodimer MHC class II, DR (6p21.3) Mold / Biotoxin Susceptibility
HLA-DPA1 and HLA-DPB1 forms HLA-DP, MHC class II, DP (6p21.3)
HLA-Cw*06:02: gene variation related to psoriasis (6p21.3)
LOC100533655: encoding protein Aryl hydrocarbon receptor pseudogene
LST1: leukocyte specific transcript 1 (6p21.33)
LY6G6E encoding protein Lymphocyte antigen 6 complex, locus G6E (pseudogene) (6p21.33)
MIR4640: microRNA 4640 (6p21.33)
MLIP: muscular LMNA interaction protein (6p12.1)
MRPS18B: mitochondrial ribosomal protein S18B (6p21.33)
MUT: methylmalonyl Coenzyme A mutase (6p12.3)
NHLRC1: NHL repeat containing E3 ubiquitin protein ligase 1 (6p22.3)
NOL7: nucleolar protein 7 (6p23)
NQO2: N-ribosyldihydronicotinamide:quinone reductase 2 (6p25.2)
NRSN1: neurensin 1 (6p22.3)
NUDT3: nudix hydrolase 3 (6p21.31)
PFDN6: prefoldin subunit 6 (6p21.32)
PHACTR1: phosphatase and actin regulator 1 (6p24.1)
PKHD1: polycystic kidney and hepatic disease 1 (autosomal recessive) (6p21.2-p12)
PRICKLE4: prickle planar cell polarity protein 4 (6p21.1)
PRSS16: protease, serine 16 (6p22.1)
PSMB8-AS1: PSMB8 antisense RNA 1 (head to head) (6p21.32)
RAB44: encoding protein Rab44, member ras oncogene family
RIPOR2: RHO family interacting cell polarization regulator 2 (6p22.3)
RPL10A: encoding protein 60S ribosomal protein L10a (6p21.31)
SKIV2L: Ski2 like RNA helicase (6p21.33)
SSR1: signal sequence receptor subunit 1 (6p24.3)
TCF19: transcription factor 19 (6p21.33)
TCP11: t-complex 11 (6p21.31)
TJAP1: tight junction associated protein 1 (6p21.1)
TP53COR1 encoding protein Tumor protein p53 pathway corepressor 1 (non-protein coding)
TMEM151B: encoding protein Transmembrane protein 151B
TNXB: tenascin XB (6p21.3)
TRAM2: translocation associated membrane protein 2 (6p12.2)
TRIM38: encoding protein Tripartite motif containing 38
TTBK1: encoding protein Tau tubulin kinase 1
UBR2: ubiquitin protein ligase E3 component n-recognin 2 (6p21.2)
UNC5CL: encoding protein Unc-5 homolog C (C. elegans)-like
VEGF: vascular endothelial growth factor A (angiogenic growth factor) (6p21.1)
VPS52: GARP complex subunit
ZKSCAN4: encoding protein zinc finger with KRAB and SCAN domains 4
ZNF76: zinc finger protein 76 (6p21.31)
ZNF193: zinc finger protein 193 (6p22.1)
ZNRD1: zinc ribbon domain containing 1 (6p22.1)
The following are some of the genes located on q-arm (long arm) of human chromosome 6:
AIM1: encoding protein Absent in melanoma 1 protein (6q21)
AIG1: encoding protein Androgen-induced protein 1 (6q24.2)
AKIRIN2: akirin 2 (6q15)
ARG1: arginase 1 (6q23.2)
BCKDHB: branched-chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) (6q14.1)
BMIQ3: body mass index QTL 3
TMEM242 encoding transmembrane protein TMEM242
C6orf58: chromosome 6 open reading frame 58 (6q22.33)
CFAP206: encoding protein Cilia And Flagella Associated Protein 206
CMD1F: cardiomyopathy, dilated 1F
CMD1K: cardiomyopathy, dilated 1K
CNR1: cannabinoid 1 receptor (6q14-q15)[13]
DFNB38: deafness, autosomal recessive 38
DYX4: dyslexia susceptibility 4
ECT2L: encoding protein Epithelial cell transforming sequence 2 oncogene-like
ESR1: Estrogen receptor 1 (6q25)
EYA4: eyes absent homolog 4 (Drosophila)(6q23.2)
FBXL4: F-box and leucine rich repeat protein 4 (6q16.1-q16.2)
FEB5: febrile convulsions 5
HACE1: HECT domain and Ankyrin repeat containing, E3 ubiquitin protein ligase 1 (6q21)
HEBP2: heme binding protein 2 (6q24.1)
IDDM8: insulin dependent diabetes mellitus 8
IDDM15: insulin dependent diabetes mellitus 15
IFNGR: interferon-γ receptor gene (6q23-q24)
IGF2R: insulin-like growth factor 2 receptor (6q25.3)
IMPG1: interphotoreceptor matrix proteoglylcan 1 (6q14.1)
KIAA0408
LGSN: encoding protein lengsin
LIN28B: lin-28 homolog B (6q16.3-q21)
MAN1A1: mannosidase alpha class 1A member 1 (6q22.31)
MB21D1: encoding protein Mab-21 domain containing 1
MCDR1: macular dystrophy, retinal, 1
MDN1: midasin AAA ATPase 1 (6q15)
MOXD1: monooxygenase DBH like 1 (6q23.2)
MTO1: mitochondrial tRNA translation optimization 1 (6q13)
MRT18: mental retardation, non-syndromic, autosomal recessive
MRT28: mental retardation, non-syndromic, autosomal recessive
MTRF1L: mitochondrial translational release factor 1 like (6q25.2)
MYO6: myosin VI (6q14.1)
OA3: ocular albinism 3
OPRM1: μ-opioid receptors (6q24-q25)
OTSC7: otosclerosis 7
PLG: plasminogen (6q26)
PBCRA1
PARK2: Parkinson disease (autosomal recessive, juvenile) 2, parkin (6q26)
PCMT1: protein-L-isoaspartate (D-aspartate) O-methyltransferase (6q25.1)
PERP: p53 apoptosis effector related to PMP-22 (6q23.3)
PKIB: cAMP-dependent protein kinase inhibitor beta (6p22.31)
PLAGL1: (6q24.2)
RCD1: retinal cone dystrophy 1
RFPL4B: Ret finger protein like 4B
RP63: retinitis pigmentosa 63
SASH1: SAM and SH3 domain containing 1 (6q24.3-q25.1)
SCZD5: schizophrenia disorder 5
SEN6: senescence (cellular)-related 6
SENP6: SUMO1/sentrin specific peptidase 6 (6q14.1)
SERAC1: serine active site containing 1 (6q25.3)
SERINC1: serine incorporator 1 (6q22.31)
SF3B5: splicing factor 3b subunit 5 (6q24.2)
SMAP1: small ArfGAP 1 (6q13)
SOBP: sine oculis binding protein homolog (6q21)
SPG25: spastic paraplegia 25
ST8: suppression of tumorigenicity 8
SYNJ2: synaptojanin 2 (6q25.3)
T: T brachyury transcription factor (more commonly known as the T gene) linked to Hepatocellular carcinoma and Chordoma (6q27)[14]
TAAR1: trace amine associated receptor 1 (6q23.1)
TAAR2: trace amine associated receptor 2 (6q24)
TMEM200A: encoding protein Transmembrane protein 200A
TSPYL1: TSPY like 1 (6q22.1)
UNC93A: encoding protein Unc-93 homolog A (C. elegans)
VNN1: vanin 1 (6q23.2)
VNN2: vanin 2 (6q23.2)
VTA1: Vesicle trafficking 1 (6q24.1-2)
ZC2HC1: encoding protein Zinc finger C2HC-type containing 1B
ZDHHC14: encoding protein Zinc finger, DHHC-type containing 14
The following diseases are some of those related to genes on chromosome 6:
ankylosing spondylitis, HLA-B
collagenopathy, types II and XI
Coeliac disease HLA-DQA1 & DQB1
Ehlers-Danlos syndrome, classical, hypermobility, and Tenascin-X types
Hashimoto’s thyroiditis
hemochromatosis
Hemochromatosis type 1
21-hydroxylase deficiency
maple syrup urine disease
methylmalonic acidemia
Autosomal nonsyndromic deafness
North Carolina macular dystrophy
otospondylomegaepiphyseal dysplasia
Parkinson disease
polycystic kidney disease
porphyria
porphyria cutanea tarda
Rheumatoid arthritis, HLA-DR
CIRS (Chronic Inflammatory Response Syndrome ), Sick Building Syndrome, Mold Toxin Susceptibility / Poisoning, HLA-DR/DQ
Spinocerebellar ataxia type 1, ATXN1
Stickler syndrome, COL11A2
Systemic lupus erythematosus
Diabetes mellitus type 1, HLA-DR, DQA1 & DQB1
X-linked sideroblastic anemia
Epilepsy
Guillain Barre Syndrome
Chordoma
Hepatocellular carcinoma
Schizophrenia
Cytogenetic band