Chromosome 3 is one of the 23 pairs of chromosomes in humans.
People normally have two copies of this chromosome.
Chromosome 3 spans 201 million base pairs and represents about 6.5 percent of the total DNA in cells.
The following is a partial list of genes on human chromosome 3.
Partial list of the genes located on p-arm (short arm) of human chromosome 3:
ALAS1: aminolevulinate, delta-, synthase 1
APEH: encoding enzyme Acylamino-acid-releasing enzyme
ARPP-21: Cyclic AMP-regulated phosphoprotein, 21 kDa
AZI2: encoding protein 5-azacytidine-induced protein 2
BRK1: SCAR/WAVE actin nucleating complex subunit
BRPF1: bromodomain and PHD finger containing 1
BTD: biotinidase
C3orf14-Chromosome 3 open reading frame 14: predicted DNA binding protein.
CFAP20DC: encoding protein Chromosome 3 open reading frame 67
C3orf62: chromosome 3 open reading frame 62
CACNA2D3: calcium channel, voltage-dependent, alpha 2/delta subunit 3
CCR5: chemokine (C-C motif) receptor 5
CGGBP1: CGG triplet repeat binding protein 1
CMTM7: CKLF like MARVEL transmembrane domain containing 7
CNTN4: Contactin 4
COL7A1: Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)
CRBN: Cereblon protein[11]
DCLK3: Doublecortin like kinase 3
DLEC1: encoding protein Deleted in lung and esophageal cancer 1
EAF1: ELL associated factor 1
ENTPD3: ectonucleoside triphosphate diphosphohydrolase 3
FAM107A: Family with sequence similarity 107 member A
FAM19A1: Family with sequence similarity 19 member A1, C-C motif chemokine like
FBXL2: F-box and leucine rich repeat protein 2
FOXP1: Forkhead Box Protein P1
FRA3A encoding protein Fragile site, aphidicolin type, common, fra(3)(p24.2)
FRMD4B encoding protein FERM domain containing 4B
GHRLOS: non-coding RNA ghrelin opposite strand (non-protein coding)
GMPPB: GDP-mannose pyrophosphorylase B
HACL1: encoding protein 2-hydroxyacyl-CoA lyase 1
HEMK1: encoding protein HemK methyltransferase family member 1
HIGD1A: HIG1 domain family member 1A
HTD2: encoding protein Hydroxyacyl-thioester dehydratase type 2
LARS2: leucyl-tRNA synthetase, mitochondrial
LIMD1: LIM domain-containing protein 1
LOC105377021: encoding protein LOC105377021
LINC00312: Long intergenic non-protein-coding RNA 312
LZTFL1: Leucine zipper transcription factor like 1
MIR138-1: encoding protein MicroRNA 138-1
MIR885: encoding protein MicroRNA 885
MITF: microphthalmia-associated transcription factor
MLH1: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
MYRIP: Myosin VIIA and Rab interacting protein
NBEAL2: Neurobeachin-like 2
NDUFAF3: encoding enzyme NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
NKTR: NK-tumor recognition protein
NPRL2: Nitrogen permease regulator 2-like protein
OXTR: oxytocin receptor
PCAF: acetyltransferase activity
PHF7 encoding protein PHD finger protein 7
PRICKLE2: encoding protein Prickle planar cell polarity protein 2
PTHR1: parathyroid hormone receptor 1
QRICH1: encoding protein QRICH1, also known as Glutamine-rich protein 1,
RBM6: RNA-binding protein 6
RPP14: Ribonuclease P protein subunit p14
SCN5A: sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)
SETD5: SET domain containing 5
SFMBT1: Scm-like with four mbt domains 1
SLC25A20: solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
STT3B: catalytic subunit of the oligosaccharyltransferase complex
SYNPR: synaptoporin
TAFA4: encoding protein Family with sequence similarity 19 member A4, C-C motif chemokine like
TCAIM: encoding protein T-cell activation inhibitor, mitochondrial
TDGF1: Teratocarcinoma-derived growth factor 1
TMEM158: Transmembrane protein 158
TMIE: transmembrane inner ear
TRAK1: trafficking kinesin-binding protein 1
TRANK1: encoding protein Tetratricopeptide repeat and ankyrin repeat containing 1
TTLL3: encoding protein Tubulin tyrosine ligase-like family, member 3
TUSC2: tumor suppressor candidate 2
UCN2: Urocortin-2
ULK4: UNC-51 like kinase 4
VGLL3: vestigial-like family member 3
VHL: von Hippel-Lindau tumor suppressor
ZMYND10: zinc finger MYND-type containing 10
ZNF197: encoding protein Zinc finger protein 197
ZNF502: encoding protein Zinc finger protein 502
ZNF620: encoding protein Zinc finger protein 620
ZNF621: encoding protein Zinc finger protein 621
ZNF717: encoding protein Zinc finger protein 717
q-arm
Partial list of the genes located on q-arm (long arm) of human chromosome 3:
ADIPOQ: adiponectin
AMOTL2: encoding protein Angiomotin-like protein 2
ARHGAP31: Rho GRPase activating protein 31
TIMMDC1: TIMMDC1
C3orf70 chromosome 3 open reading frame 70
CAMPD1: Camptodactyly
CCDC80: Coiled-coil domain containing protein 80
CD200R1: Cell surface glycoprotein CD200 receptor 1
CHST13: encoding protein Carbohydrate (chondroitin 4) sulfotransferase 13
CLDND1: Claudin domain containing 1
CPN2: Carboxypeptidase N subunit 2
CPOX: coproporphyrinogen oxidase (coproporphyria, harderoporphyria)
DPPA2: Developmental pluripotency associated 2
DTX3L: encoding protein Deltex e3 ubiquitin ligase 3l
DZIP3: encoding protein DAZ interacting zinc finger protein 3
EAF2: ELL associated factor 2
EFCC1: EF-hand and coiled-coil domain containing 1
ETM1: Essential tremor 1
ETV5: ETS variant 5
FAM3D: family with sequence similarity 3, member D
FAM43A: family with sequence similarity 43 member A
FAM162A: family with sequence similarity 162 member A
FBXO40: encoding protein F-box protein 40
FILIP1L: encoding protein Filamin A interacting protein 1 like
GYG1: Glycogenin-1
HACD2 encoding protein 3-hydroxyacyl-CoA dehydratase 2
HGD: homogentisate 1,2-dioxygenase (homogentisate oxidase)
IFT122: intraflagellar transport gene 122
KIAA1257: KIAA1257
LINC01279: encoding protein long intergenic non-protein coding RNA 1279
LNCR5: encoding protein lung cancer susceptibility 5
LMLN: encoding protein Leishmanolysin-like (metallopeptidase M8 family)
LRRC15: leucine rich repeat containing 15
LSG1: large subunit GTPase 1 homolog
MB21D2: encoding protein Mab-21 domain containing 2
MCCC1: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
MORC1: encoding protein Morc family cw-type zinc finger 1
MYLK: Telokin
NEPRO: encoding protein Nucleolus and neural progenitor protein
NFKBIZ: NF-kappa-B inhibitor zeta
OTOL1: encoding glycoprotein Otolin
PARP14 encoding protein Poly(ADP-ribose) polymerase family member 14
PCCB: propionyl Coenzyme A carboxylase, beta polypeptide
PDCD10: programmed cell death 10
PIK3CA: phosphoinositide-3-kinase, catalytic, alpha polypeptide
PISRT1: long non-coding RNA
PROSER1: Proline and serine rich protein 1
RAB7: RAB7, member RAS oncogene family
RASA2: encoding protein Ras p21 protein activator 2
RETNLB: resistin-like beta
RHO: rhodopsin visual pigment
RIOX2: Ribosomal oxygenase 2
SELT: Selenoprotein T
SENP7: Sentrin-specific protease 7
SERP1: Stress-associated endoplasmic reticulum protein 1
SOX2: transcription factor
SOX2OT: SOX2 overlapping transcript
SPG14 encoding protein Spastic paraplegia 14 (autosomal recessive)
SRPRB: Signal recognition particle receptor subunit beta
TEX55: encoding protein Testis expressed 55
TMEM44: encoding protein Transmembrane protein 44
TM4SF1: Transmembrane 4 L6 family member 1
TMPRSS7: encoding protein Transmembrane serine protease 7
TP63: Tumor protein p63
TRAT1: T-cell receptor-associated transmembrane adapter 1
USH3A: Usher syndrome 3A
ZBED2: encoding protein Zinc finger BED-type containing 2
ZNF9: zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)
The following diseases and disorders are some of those related to genes on chromosome
3-Methylcrotonyl-CoA carboxylase deficiency
3q29 microdeletion syndrome
Acute myeloid leukemia (AML)
Alkaptonuria
Arrhythmogenic right ventricular dysplasia
Atransferrinemia
Autism
Autosomal dominant optic atrophy
ADOA plus syndrome
Biotinidase deficiency
Blepharophimosis, epicanthus inversus and ptosis type 1
Breast/colon/lung/pancreatic cancer
Brugada syndrome
Castillo fever
Carnitine-acylcarnitine translocase deficiency
Cataracts
Cerebral cavernous malformation
Charcot–Marie–Tooth disease, type 2
Charcot–Marie–Tooth disease
Chromosome 3q duplication syndrome
Coproporphyria
A location on human chromosome 3 is associated with respiratory failure and possibly with increased severity in COVID-19
Dandy–Walker syndrome
Deafness
Diabetes
Dystrophic epidermolysis bullosa
Endplate acetylcholinesterase deficiency
Essential tremors
Ectrodactyly, Case 4
Glaucoma, primary open angle
Glycogen storage disease
Hailey–Hailey disease
Harderoporphyrinuria
Heart block, progressive/nonprogressive
Hereditary coproporphyria
Hereditary nonpolyposis colorectal cancer
HIV infection, susceptibility/resistance to
Hypobetalipoproteinemia, familial
Hypothermia
Leukoencephalopathy with vanishing white matter
Long QT syndrome
Lymphomas
Malignant hyperthermia susceptibility
Metaphyseal chondrodysplasia, Murk Jansen type
Microcoria
Möbius syndrome
Moyamoya disease
Mucopolysaccharidosis
Muir–Torre family cancer syndrome
Myotonic dystrophy
Neuropathy, hereditary motor and sensory, Okinawa type
Night blindness
Nonsyndromic deafness
Ovarian cancer
Porphyria
Propionic acidemia
Protein S deficiency
Pseudo-Zellweger syndrome
Retinitis pigmentosa
Romano–Ward syndrome
Seckel syndrome
Sensenbrenner syndrome
Septo-optic dysplasia
Short stature
Spinocerebellar ataxia
Sucrose intolerance
T-cell leukemia translocation altered gene
Usher syndrome
von Hippel–Lindau syndrome
Waardenburg syndrome
Xeroderma pigmentosum, complementation group c
Cytogenetic band
G-banding ideograms of human chromosome 3