Manufactured chemical production has increased exponentially and has resulted in wide spread environmental dissemination and extensive human exposure.
Three classes of manufactured chemicals have been implicated in disease and especially increased risk of cardiovascular disease: halogenated hydrocarbons, perfluoroalcohol substances (PFAS), and plastic associated chemicals.
Halogenated hydrocarbons include: polychlorinated biphenyls, dioxins, brominated flame retardants and organochlorine pesticides.
Halogenated hydrocarbons are lipophilic, bioaccumulative, and highly persistent in living organisms and the environment.
These agents have been banned, but remain abundant in the environment.
Halogenated hydrocarbons consumption of contaminated meat and fish is the main human exposure route.
Perfluoroalcohol substances are used in water repellent and fire fighting foams and are strongly linked to obesity and type two diabetes.
Plastic associated chemicals include: bisphenol A and phallates which are abundant in personal care products, food preservatives, pharmaceuticals, and paper products.
Plastic associated chemicals are associated with dyslipidemia, insulin resistance, and obesity.Chemical pollutants