Earliest recognizable pathological event in Alzheimer’s disease is cerebral amyloid-beta aggregation.
Cerebral amyloid-beta baby present 20 years before the onset of dementia and Alzheimer’s disease.
Cerebral amyloid can be assessed by cerebral spinal fluid biomarkers and by positron emission tomography.
Amyloid pathology in non-demented individuals is variable, from 10-70%.
Amyloid beta pathology is associated with age, APOE genotype and the presence of cognitive impairment.
Cerebral amyloid angiopathy is a common cause of lobar intracranial hemorrhage in the elderly, particularly among those on anticoagulant therapy.
Cerebral amyloid angiopathy intracerebral hemorrhage on anticoagulant therapy has a high mortality rate.
A cerebral amyloid angiopathy related intracranial hemorrhage has a higher risk for recurrence compared with hypertensive related intracranial hemorrhage.