A tumor necrosis factor receptor family member.

Conveys signals that regulate proliferation and differentiation, cell growth suppression and cell death.

Expressed on B- cells, macrophages, dendritic cells, endothelial cells, and fibroblasts.

Widespread expression accounts for its role in the regulation of immune responses and host defenses.

Binding of CD 40 acts on antigen presenting cells and T cells in a bidirectional manner, and mediates humoral and cellular immune responses.

CD40-CD40L Coast, stimulatory pathway regulates the  adaptive, and innate immune responses.

The CD40 – CD 40 L pathway may involved in multiple sclerosis and its association with disease progression, with possible links to peripheral immune tolerance and Epstein-Barr virus infection induced by CD 40 L expression.

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