Various malignancies, including T-cell lymphomas and solid tumors have high C-C chemokine receptor 4 (CCR4) expression.

CCR4 plays a role in the homing of memory T cells to peripheral tissues, such as the skin.

Cutaneous T-cell lymphomas which arise from skin resident memory lymphocytes express CCR 4.

CCR4 can be targeted with a monoclonal antibody Mogamulizumab in mycosis fungoides and Sezary syndrome.

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