Various malignancies, including T-cell lymphomas and solid tumors have high C-C chemokine receptor 4 (CCR4) expression.
CCR4 plays a role in the homing of memory T cells to peripheral tissues, such as the skin.
Cutaneous T-cell lymphomas which arise from skin resident memory lymphocytes express CCR 4.
CCR4 can be targeted with a monoclonal antibody Mogamulizumab in mycosis fungoides and Sezary syndrome.