Cardiovascular-kidney-metabolic syndrome

Cardiovascular-kidney metabolic syndrome (CKMS) also known as cardiorenal metabolic syndrome or cardiometabolic syndrome.

CKMS refers to a clustering of risk factors that increase the risk of cardiovascular diseases (CVD) and kidney diseases. 

CKMS is involves a combination of metabolic abnormalities, including obesity, high blood pressure, insulin resistance, dyslipidemia and high blood sugar.

The presence of CKMS increases the likelihood of developing conditions such as heart disease, stroke, chronic kidney disease, type 2 diabetes, and other related disorders. 

Causal factors for CKMS: genetic predisposition, unhealthy lifestyle habits like sedentary lifestyle, poor diet, and hormonal imbalances may contribute to its development.

The interactions between metabolic risk factors, such as type 2 diabetes and obesity, with chronic kidney disease and cardiovascular disorders lead to an increased mortality risk and significant impact on morbidity.

Excess or dysfunctional adiposity is a source of proinflammatory and prooxidative secretions that cause tissue injury and insulin resistance.

Metabolic risk factors include: hypertension, hyperglycemia,hypertrglyceridemia, high-risk chronic kidney disease.

Excessive body fat and related insulin resistance are the main cause of the CKMS.

Inflammation, dyslipidemia, hypertension and insulin resistance accelerate arteriosclerotic cardiovascular disease.

Managing cardiovascular-kidney metabolic syndrome:

 Lifestyle modifications including maintaining a healthy weight, regular physical activity, adopting a balanced and nutritious diet, managing blood pressure and cholesterol levels, and controlling blood sugar levels if diagnosed with diabetes. 

In some cases, medication may be prescribed to help manage specific risk factors: use of sodium glucose transport protein 2(SGLT2) may improve treatment outcomes.


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