Malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/connective tissue cancer).

Can arise in diverse organs, such as the skin, salivary glands, lungs, the esophagus, pancreas, colon, uterus and ovaries.

A rare and particularly aggressive subtype of endometrial cancer with limited treatment options.

Contain both epithelial and mesenchymal elements.

Most commonly associated with mixed Müllerian tumors of the uterus.

Frequently present with triad of painful postmenopausal bleeding, an enlarged uterus, and prolapsed tumors visible at the cervical os.

Surgery routinely includes lymphadenectomy.

Median progression free survival of less than 2 months and 6 month progressive free survival less than 20%.

May respond to Cabozantinib.

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