Higher cancer-specific mortality, recurrence scores in Black women with breast cancer.
Black women have a greater likelihood for aggressive ER-positive tumors, and a less well-defined prognosis
High-risk recurrence scores and higher breast cancer-specific mortality are more likely in Black women with estrogen receptor (ER)-positive, ERBB2-negative, axillary lymph node-negative breast cancer, according to analysis of data from the Surveillance, Epidemiology, and End Results (SEER) Oncotype database.
Across all risk groups, Black women had a significantly increased hazard of breast cancer-specific mortality compared with non-Hispanic White women.
Breast cancer-specific mortality rates were higher for Black women with axillary node-negative tumors and recurrence scores of 0-10 compared with non-Hispanic White women with the same risk factors.
Breast cancer-specific mortality rates were also higher for Black women with recurrence scores of 11-25 and for Black women with scores greater than 25.
This study found that Black women are more likely to have a high-risk recurrence score and to die of axillary node-negative breast cancer compared with women of other race/ethnicity with the same recurrence score.
Black women are more likely to have high risk recurrence scores and die of axillary node-negative breast cancer compared with non-Hispanic White women.