Associated with a significant risk of neoplasms among recipients of BMT.
Engraftment defined as the first 3 consecutive days of an absolute neutrophil count 500 or more.
Oral neutrophil recovery precedes blood neutrophil engraftment and the day of neutrophil detection in an oral rinse predicts for patient susceptibility to infection following transplant.
Development of a new solid cancer approximately 1.6% at 5 years, 6% at 10 years and 15% at 15 years.
Complications include graft-vs-host disease , recurrent infections, pulmonary problems, cataract formation, osteoporosis, avascular necrosis, premature onset of menopause, fertility problems and malignancies.
Physical recovery occurs before psychological or work recovery.
Full recovery takes 3-5 years.
More than half of donors of bone marrow or peripheral stem cells have CMV antibodies indicative of active or latent infections which can be transmitted to graft recipients.