1864
Also known as punctate basophilia.
Refers to the presence of numerous basophilic granules that are dispersed through the cytoplasm of erythrocytes in a peripheral blood smear.
Demonstrated to be RNA.
Composed of aggregates of ribosomes, although degenerating mitochondria and siderosomes may be included in the aggregates.
In contrast to Pappenheimer bodies, there is no iron in basophilic stippling.
It is an indication of disturbed erythropoiesis.
It can also be found in some normal individuals.
It is associated with:
Thalassemia[2] (β-thalassemia Minor (i.e Trait) & Major, and α-thalassemia
Severe megaloblastic anemia
Hemolytic anemia
Sickle-cell anemia
Pyrimidine 5′ nucleotidase deficiency
Alcoholism
Myelodysplastic syndromes
Sideroblastic anemia
Congenital dyserythropoietic anemia
Primary myelofibrosis
Leukemia
Erythroleukemia
Hemorrhage
Unstable hemoglobins
Altered hemoglobin biosynthesis
Heavy metal poisoning
Lead poisoning
Zinc
Arsenic
Silver
Mercury