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Autoimmune gastritis

Atrophic gastritis is characterized by chronic inflammation of the gastric mucosa

Associated with loss of gastric glandular cells and replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue.

Atrophy of the gastric mucosa, such as chronic gastritis associated with Helicobacter pylori infection, other unidentified environmental factors, and autoimmunity directed against gastric glandular cells.

Helicobacter pylori chronic active gastritis.

A mononuclear lymphoplasmacytic and polymorphonuclear cell infiltrate is observed in the mucosal tissues.ppp

There are 2 main causes of atrophic gastritis result in distinct topographic types of gastritis, which can be distinguished histologically.

Autoimmune gastritis essentially is restricted to the gastric corpus and fundus.

Individuals with autoimmune gastritis may develop pernicious anemia due to loss of parietal cells and the presence of anti-intrinsic factor antibodies.

H pylori- associated atrophic gastritis is frequently asymptomatic.

H pylori- associated atrophic gastritis associated with an increased risk of developing gastric carcinoma.

Patients with chronic atrophic gastritis develop low gastric acid output and hypergastrinemia, which may lead to enterochromaffin-like cell hyperplasia and carcinoid tumors.

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