H1-first generation such as diphenhydramine or chlorpheniramine which can cause drowsiness, impair learning, decrease work productivity and impair psychomotor performance.
H1-second generation agents have fewer central nervous system adverse effects than first generation drugs.
H1 second generation drugs include loratidine, desloratadine, fexofenadine and cetirizine.
The second-generation antihistamines have a rapid onset of action and do not cross the blood-brain barrier.
The second-generation antihistamines have minimal anticholinergic activity and less drowsiness, than first generation antihistamines.
First-generation antihistamines associated with impaired learning and school performance in children.
The second-generation antihistamines can be used as needed for rhinitis symptoms, but they generally are more effective with continuous use.1
The second-generation antihistamines can be used as needed for rhinitis symptoms, but they generally are more effective with continuous use.
Oral suspensions are available and ease administration and compliance in young children.