Antihemophiliac Factor Recombinant , Fc Fusion Protein

Trade name Eloctate.

A recombinant DNA derived, anti-hemophiliac factor indicated in adults and children with hemophilia A for: Control and prevention of bleeding episodes, perioperative management, and routine prophylaxis to prevent or reduce the frequency of bleeding episodes.

Mean terminal half-life after a sinle 50 IU/kg in adults.

Regimen ranges of 25-65 IU/kg at 3-5 day intervals.

Higher doses of up to 80 IU/kg may be needed in children <6 years of age.

One- stage clotting assay or chromogenic assay used to monitor plasma factor VIII levels.

With prophylactic 0 bleeds occur in 45% of patients.

Use not associated with inhibitors, or anaphylaxis.

Low incidence of adverse reactions, with about 1% arthralgias and malaise with 0.6% abdominal pain, bradycardia, chest pain, cough, dizziness, myalgias, joint swelling, hypertension, and rash.

Not indicated for the treatment of von Willebrand’s disease.

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