Associated with unexplained fever, dyspnea, weight gain, pulmonary congestion, pulmonary infiltrates, pleural and/or pericardial effusions with or without leukocytosis seen when patients are treated with arsenic trioxide/ATRA/ chemotherapy.
Also known as cytokines release syndrome.
High-dose corticosteroids is the treatment and should be continued for 3 days or until signs have abated.
With differentiation syndrome patients should be treated with intravenous steroids to prevent treatment-related mortality.
It may be appropriate to reduce doses of anthracycline in older patients and children and adolescents to minimize morbidity