Common complication in hospitalized patients.
A prevalent, serious, and frequently preventable condition that affects 5%-7% of hospital admissions and 20-50% of ICU admissions.
A newer term for acute renal failure.
Incidence is increasing globally.
Occurs in 2-5% of hospitalized adults with a major effect on morbidity and healthcare utilization.
Defined is an acute increase in serum creatinine concentration of greater than 50% or an acute increase of greater than 0.3 mg per deciliter.
Definitions of AKI uses 2 functional biomarkers: increased serum creatinine concentration and decreased urine output.
Serum creatinine level is a late disease market, often increasing at 24-48 hours after the initial kidney insult.
There is no pharmacological interventions available to prevent or treat AKI.
Acute kidney injury refers to an increase in serum creatinine within 2-7 days or oliguria.
Associated with substantially increased morbidity and mortality rates.
The largest burden occurs in critically ill patients and patients with cardiovascular disease, who are at increased risk for both acute kidney injury and chronic kidney disease owing to older age and multiple coexisting conditions, and the greater likelihood of undergoing procedures that directly affect kidney function, such as coronary angiograms or cardiac surgery.
Development of AKI in patients with sepsis is associated with increased mortality, and survivors are at risk of developing chronic kidney disease.
A delay in detection and intervention allows it it to progress to more severe stages and contributes to the development of chronic kidney disease after hospital discharge.
Mortality rates and length of stay increase with progressive severity of acute kidney injury.
Sepsis associated AKI is associated with inflammatory, nephrotoxic, and ischemic insults occurring simultaneously leading to kidney impairment.
Acute kidney diseases refers to less than three months of having decreased kidney function or the presence of a marker of kidney damage and include kidney injury.
About 10% of the 200 million adults are estimated to have undergone major noncardiac surgery each year develop acute kidney injury.
Occurs in approximately 20% of hospitalizations.
Occurs in up to 60% of patients in ICUs and it’s incidence is increasing.
Essential pathogenesis are inflammation and oxidative stress, implicating multiple subtypes of immune cells.
Soluble urokinase plasminogen activator receptor (suPAR) is normally expressed at low levels on endothelial cells, podocytes and with induced expression immunologically active cells such as monocytes and lymphocytes: levels are predictive of progressive decline and kidney function.
suPAR Elevation results in proteinuria.
AKI requiring renal replacement therapy after cardiac surgery affects approximately 5% of patients admitted to the ICU and is associated with the mortality rate of up to 60%.
AKI requiring renal replacement occurs in approximately 1-2% of patients after cardiac surgery.
AKI survivors have higher risk of developing chronic kidney disease, cardiovascular disease, sepsis, and upper G.I. bleeding.
AKI the strongest risk factor for postoperative mortality having an odds ratio of 7.9 and a mortality in excess of 60%.
Particularly common following cardiac surgery.
Acute kidney injury complicates cardiac surgery in up to 30% of patients.
Even mild postoperative acute kidney injury associated with a 5-fold increase in death while in the hospital.
Acute kidney injury following cardiac surgery associated with higher rates of postoperative arrhythmias, respiratory failure, systemic infection, and myocardial infarction.
Among patients undergoing cardiac surgery, perioperative statins do not reduce the risk of acute kidney injury.
Develops in one of five patients with acute myocardial infarction.
AKI associated with increased hospital duration, increased risk for infection, increased cost, increased mortality, and increased risk of end-stage kidney disease.
Perioperative acute kidney injury associated with longer hospital stay is, poor outcomes, and higher healthcare costs.
Most common cause of hospital acquired AKI is acute tubular necrosis.
After cardiac surgery renal and especially medullary ischemia is presumed to be in mechanism of renal injury from surgery.
The magnitude of creatinine increase after cardiac surgery is associated in a graded manner with an increased risk of chronic kidney disease, chronic kidney disease progression and mortality (Ishani A et al).
In a study of 29,388 individuals that underwent cardiac surgery and increase in creatinine level, even of mild severity, was associated with a subsequent increase in the risk of incident chronic kidney disease, kidney disease progression, and mortality: this increased risk is most pronounced during the 3-24 months after an episode of creatinine increase (Ishani A et al). in
RIFLE Classification System for Acute Kidney Injury (Risk of renal dysfunction, Injury to the kidney, Failure or Loss of kidney function, and End-stage renal disease)
RIFLE criteria has three stages of acute kidney injury-risk, injury, and failure.
RIFLE criteria has two outcome measures loss of renal function, and ESRD.
Acute kidney injury defined as an absolute increase in serum creatinine of more than or equal to 0.3 mg/dL, a percentage increase in serum creatinine of more than or equal to 50%, or a reduction in urine output of less than 0.5 mL/kg per hour for more than 6 hours.
Magnitude of renal injury is determined by the level of creatinine, or GFR and urinary output.
The development of AKI is associated with long term adverse consequences including permanent renal impairment and end-stage renal disease.
Minor increases in serum creatinine are associated with increased hospital and long-term mortality, and longer length of stay.
Many intravenous fluids used for hydration and resuscitation contain supra physiological concentrations of chloride, which can induce or exacerbate hyperchloremia and metabolic acidosis, and result in renal vasoconstriction and decreased GFR.
Hyperchloremic metabolic acidosis prolong time to micturition and decreased urine output following major surgery.
In a prospective, open label, sequential. pilot study of patients admitted consecutively to the ICU a chloride restrictive strategy was associated with a significant decrease in the incidence of acute kidney injury and the use of renal replacement therapy (Younos NM et al).
In the study of 30,000 surgical patients saline therapy increased the risk of patients requiring acute dialysis compared with Plasma-Lyte administration (Shaw AD et al).
The RIFLE criteria has limitations in that they can not distinguish between prerenal azotemia as opposed to intrinsic renal disease or obstructive nephropathy, volume changes can influence creatinine levels, and an interval lag exists between the above criteria and the development of structural damage. Him him him
Incidence has-been increasing from approximately 10-25 per 1000 discharges over the last 15 years ( Walkar SS et al).
Associated with increased mortality.
Initial evaluation usually includes real ultrasound to exclude obstruction, and if such up structure and is present it may require further intervention.
Elevations in serum creatinine of as little as 0.3 mg/dL is associated with a higher mortality rate in hosptialized patients (Chertow GM et al).
Most cases are not caused by obstruction and hydronephrosis is identified on real ultrasound in only one-10% of patients.
In a sample of 200 patients, seven factors were associated with hydronephrosis and they include a history of hydrnephrosis, recurrent urinary tract infections, nonblack race, diagnosis consistent with obstruction, absence of exposure to the nephrotoxic medications, congestive heart failure or pre-renal acute kidney injury.
Majority of ultrasound studies to rule out obstruction are negative.
Multiple risk factors for the presence of hydronephrosis as a cause of acute kidney injury include: history of hydronephrosis, history of prior pelvic malignancy, history of prior pelvic surgery, history of prior pelvic radiation, and history of a single functioning kidney.
In a randomized trial of 6,905 patients undergoing noncardiac surgery randomized to take aspirin or placebo before surgery and then aspirin and placebo daily for 30 days after surgery and also assigned to take oral clonidine or placebo 2 to 4 hours before surgery and transdermal clonidine patch or placebo after surgery for 72 hours: neither aspirin nor clonidine administered perioperative leak in patients undergoing major noncardiac surgery reduced the risk of acute kidney injury (Garg AX et al).
30% of acute kidney injury episodes in hospitalized patients could be avoided if physicians had taken appropriate preventive actions (Yamout H et al).
Soluble urokinase plasminogen activator receptor (suPAR) is a signaling glycoprotein involved in the pathogenesis of kidney disease: high levels are associated with acute kidney injury in various clinical contexts (Hayek SS).