Acitretin (brand name Soriatane) is an oral retinoid used to treat severe, resistant psoriasis by slowing skin cell growth and reducing inflammation.
Common side effects include dry skin, lips, and eyes, while severe risks include, birth defects, liver toxicity, and increased blood lipids.
It is taken daily with meals, often requiring 2–3 months for full effect.
Primary Use: Severe plaque psoriasis, pustular psoriasis, and erythrodermic psoriasis.
As a derivative of Vitamin A, it regulates skin cell proliferation and differentiation.
Highly teratogenic; it causes severe birth defects and must not be used by women who are pregnant or may become pregnant within 3 years after stopping the drug.
Alcohol must be avoided during treatment and for 2 months after, as it can increase the risk of creating a related compound, etretinate, that stays in the body longer.
Regular blood tests for liver function and lipid levels (cholesterol/triglycerides) are necessary.Sun Sensitivity: Increased risk of sunburn; strict sun protection is required.
Common Side Effects: Cheilitis, hair loss, skin peeling, dry mouth, and dry eyes.
Drug Interactions: Avoid Vitamin A supplements and methotrexate.
Psoriasis may temporarily worsen during the first few weeks of treatment.