Acetazolamide

A carbonic anhydrase inhibitor used to treat acute mountain sickness and high altitude periodic breathing.

A respiratory stimulant.

Used as a respiratory stimulant in patients with COPD and metabolic alkalosis.

The drug of choice for prevention of acute mountain sickness.

Mechanism of respiratory stimulation is based on the inhibition of renal carbonic anhydrase enzyme, which decreases serum bicarbonate and arterial pH, leading to increased minute ventilation via stimulation of peripheral and central chemoreceptors.

The primary mechanism combating hypobaric hypoxia of high altitude is through a bicarbonate diuresis that induces a compensatory respiratory alkalosis.

Increases nocturnal oxygen saturation and partially improves sleep apnea in otherwise untreated obstructive sleep apnea patients at altitude.

Patients with obstructive sleep apnea spending three days at moderately elevated altitude, combination of acetazolamide and auto CPAP therapy compared to auto CPAP alone resulted in improved nocturnal oxygen saturation and apnea/hypopnea index ( Latshang TD et al).

Reduces the activity of carbonic acid in the body.

Used to treat glaucoma and may be part of treatment plans for congestive heart failure and seizure disorders.

May cause dizziness, drowsiness and increase the sensitivity of your skin to sunlight.

A sulfa-based drug.

Trade name Diamox.

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